On Saturday, Pence will attempt to soothe allies unnerved by his boss' unorthodox statements on Russia and NATO as he stresses America's commitment to Europe during the first major foreign address for the Trump administration.
Pence will tell the annual Munich Security Conference that Europe is an "indispensable partner" for the United States, a message he will repeat privately in meetings with a dozen leaders over the weekend and on Monday, a senior White House foreign policy adviser told reporters.
"We are the most secure and most prosperous when both the U.S. and Europe are strong and united," the adviser said, previewing Pence's trip.
In Munich, Pence will hold a series of meetings with leaders, including German Chancellor Angela Merkel, Ukrainian President Petro Poroshenko, and leaders from Estonia, Latvia and Lithuania.
Pence will emphasize that Russia and Ukraine need to fully implement the Minsk ceasefire agreement, and will stand firm on economic sanctions on Russia related to its aggression in Ukraine, the adviser told reporters.
He plans to discuss counterterrorism in a meeting with Afghan President Ashraf Ghani, and the fight against Islamic State in meetings with Iraqi Prime Minister Haider al-Abadi and Turkish Prime Minister Binali Yildirim, the adviser said.
On Monday, Pence will hold several discussions with European officials in Brussels, including with NATO Secretary-General Jens Stoltenberg.